🗞️Amazon's GLP-1 weight loss program

In partnership with

April 21st, 2026

What happened today 🇺🇸,

• Amazon One Medical is launching a nationwide GLP‑1 weight-loss program that embeds drugs like Ozempic and Wegovy into primary care, offering virtual and in‑person visits, regular lab monitoring, and integration with Amazon Pharmacy for home delivery and transparent pricing

• The second round of U.S.‑Iran peace talks in Pakistan effectively fell apart, with Iran saying it will not attend under the current U.S. naval blockade…VP Vance and other representatives put their trip to Pakistan on hold and President Trump later in the day extended the U.S. ceasefire with Iran but announced the blockade will remain in place

• Axios reported President Trump has told confidants that Florida Governor, Ron DeSantis, is "begging" for a job in his administration, including interests in attorney general, secretary of defense, or even a spot on the U.S. Supreme Court

• A new Gallup report showed that 19.1% of U.S. adults currently have or are being treated for depression in Q1 of 2026, which is near the 20% record from late 2025 and is up from 10.5% in 2015

• House of Representatives member, Sheila Cherfilus-McCormick (D-FL), officially resigned from Congress amid allegations that she stole pandemic relief funds

• President Trump’s nominee for Federal Reserve chair, Kevin Warsh, appeared before the Senate Banking Committee for his confirmation hearing today, where he pledged to keep the Fed independent and said Trump has not demanded rate cuts from him…read more here

• Florida’s attorney general has launched a criminal investigation into OpenAI after court records showed the suspect in last year’s Florida State University shooting exchanged hundreds of messages with ChatGPT while planning the attack

• The Gates Foundation plans to cut up to 500 jobs, about 20% of its staff, over the next several years as part of an effort to limit operating costs and has also launched an external review of its past interactions with Jeffrey Epstein

• Steak ’n Shake has hired Michael Boes as its first Chief “Make America Healthy Again” (MAHA) Officer

• Meta is installing software on U.S. employees’ computers that records mouse movements, clicks, keystrokes, and occasional screen snapshots in certain work apps to generate training data for its AI models

• S&P down .63% / Nasdaq down .59% / DOW down .59%

Someone just spent $236,000,000 on a painting. Here’s why it matters for your wallet.

Late last year, a Klimt sold for the highest price ever paid for modern art at auction.

An outlier sure, but it wasn't a fluke. U.S. auction sales grew 23.1% in 2025. The $1-5mm segment even grew 40.8% YoY.

Now, the S&P, teetering on all time highs, just posted its worst quarter since 2022, oil was up 94% (briefly), and Moody's puts recession odds at 48.6%.

So, that's where it gets interesting.

Each environment is unique, but after dot-com, post war and contemporary art grew about 24% annually for a decade. After 2008, about 11% for 12 years.

It’s also had near-zero correlation with the S&P 500 since ‘95.*

Now, Masterworks lets you invest in shares of artworks featuring legends like Banksy, Basquiat, and Picasso.

• $1.3 billion invested across over 500 artworks.

• 28 sales to date.

• Net annualized returns on sold works held 12 months+ like 14.6%, 17.6%, and 17.8%.

Shares can sell quickly, but my subscribers can skip the waitlist:

Skip waitlist

^{*Investing involves risk. Past performance is not indicative of future returns. See important Reg A disclosures at masterworks.com/cd.}

Plus: A look at the share of households earning $200k+

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Quote of the day: “Education is the passport to the future, for tomorrow belongs to those who prepare for it today.” —Malcolm X

Have a great night!

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